Activating Compound | Comment | Organism | Structure |
---|---|---|---|
bile salt | required for activity | Rattus norvegicus | |
phosphatidylserine | required for activity | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
glutathione | - |
Bos taurus | |
glutathione | 3 mM, 95% inhibition | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Rattus norvegicus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required for activity | Rattus norvegicus | |
Mg2+ | required for activity | Bos taurus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
46000 | - |
x * 97000 + x * 46000, the 46000 Da subunit may also be a degradation product | Bos taurus |
97000 | - |
x * 97000 + x * 46000, the 46000 Da subunit may also be a degradation product | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingomyelin + H2O | Rattus norvegicus | - |
N-acylsphingosine + choline phosphate | - |
? | |
sphingomyelin + H2O | Bos taurus | - |
N-acylsphingosine + choline phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
brain | - |
Bos taurus | - |
intestine | exclusively expressed in intestine, lack of bSMase may be related to colon carcinogenesis | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingomyelin + H2O | - |
Rattus norvegicus | N-acylsphingosine + choline phosphate | - |
? | |
sphingomyelin + H2O | - |
Bos taurus | N-acylsphingosine + choline phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 97000 + x * 46000, the 46000 Da subunit may also be a degradation product | Bos taurus |
Synonyms | Comment | Organism |
---|---|---|
alkaline sphingomyelinase | - |
Rattus norvegicus |
bSMase | - |
Rattus norvegicus |
neutral sphingomyelinase | - |
Rattus norvegicus |
neutral sphingomyelinase | - |
Bos taurus |
nSMase | - |
Rattus norvegicus |
nSMase | - |
Bos taurus |