Any feedback?
Literature summary for 3.1.4.12 extracted from
- Sphingomyelinases: enzymology and membrane activity (2002), FEBS Lett., 531, 38-46.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| bile salt | required for activity | Rattus norvegicus |  |
| phosphatidylserine | required for activity | Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| glutathione | - |
Bos taurus | |
| glutathione | 3 mM, 95% inhibition | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Rattus norvegicus | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required for activity | Rattus norvegicus | |
| Mg2+ | required for activity | Bos taurus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 46000 | - |
x * 97000 + x * 46000, the 46000 Da subunit may also be a degradation product | Bos taurus |
| 97000 | - |
x * 97000 + x * 46000, the 46000 Da subunit may also be a degradation product | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sphingomyelin + H2O | Rattus norvegicus | - |
N-acylsphingosine + choline phosphate | - |
? | |
| sphingomyelin + H2O | Bos taurus | - |
N-acylsphingosine + choline phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| brain | - |
Bos taurus | - |
| intestine | exclusively expressed in intestine, lack of bSMase may be related to colon carcinogenesis | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sphingomyelin + H2O | - |
Rattus norvegicus | N-acylsphingosine + choline phosphate | - |
? | |
| sphingomyelin + H2O | - |
Bos taurus | N-acylsphingosine + choline phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 97000 + x * 46000, the 46000 Da subunit may also be a degradation product | Bos taurus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alkaline sphingomyelinase | - |
Rattus norvegicus |
| bSMase | - |
Rattus norvegicus |
| neutral sphingomyelinase | - |
Rattus norvegicus |
| neutral sphingomyelinase | - |
Bos taurus |
| nSMase | - |
Rattus norvegicus |
| nSMase | - |
Bos taurus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
