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Literature summary for 3.1.4.12 extracted from

  • Lansmann, S.; Schuette, C.G.; Bartelsen, O.; Hoernschemeyer, J.; Linke, T.; Weisgerber, J.; Sandhoff, K.
    Human acid sphingomyelinase: Assignment of the disulfide bond pattern (2003), Eur. J. Biochem., 270, 1076-1088.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in SF21 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Homo sapiens 5764
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
72000
-
1 * 72000 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingomyelin + H2O Homo sapiens
-
N-acylsphingosine + choline phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
haSMase deficiency due to mutations in haSMase gene leads to Niemann-Pick disease, an autosomal recessive sphingolipidosis
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Homo sapiens
additional information identification of disulfide bond pattern Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
recombinant and native haSMase Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
13.3
-
recombinant haSMase Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O
-
Homo sapiens N-acylsphingosine + choline phosphate
-
?

Subunits

Subunits Comment Organism
monomer 1 * 72000 Homo sapiens

Synonyms

Synonyms Comment Organism
acid sphingomyelinase
-
Homo sapiens
haSMase
-
Homo sapiens