Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cardiolipin | anionic phospholipids required for activity, maximal activation at 1 mM, 21% of activation with phosphatidylserine | Plasmodium falciparum | |
phosphatidic acid | anionic phospholipids required for activity, maximal activation at 1 mM, 33% of activation with phosphatidylserine | Plasmodium falciparum | |
phosphatidylglycerol | anionic phospholipids required for activity, maximal activation at 1 mM, 79% of activation with phosphatidylserine | Plasmodium falciparum | |
phosphatidylinositol | anionic phospholipids required for activity, maximal activation at 1 mM, 53% of activation with phosphatidylserine | Plasmodium falciparum | |
phosphatidylserine | anionic phospholipids required for activity, maximal activation at 1 mM | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
scyphostatin | 0.005 mM, 50% inhibition, complete inhibition at 0.033 mM | Plasmodium falciparum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1 | - |
sphingomyelin | 37°C, pH 7.5 | Plasmodium falciparum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Plasmodium falciparum | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required for activity, half-maximal activation at 1 mM | Plasmodium falciparum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingomyelin + H2O | Plasmodium falciparum | - |
N-acylsphingosine + choline phosphate | - |
? | |
sphingomyelin + H2O | Plasmodium falciparum Honduras 1 | - |
N-acylsphingosine + choline phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
no. 1-CDC | - |
Plasmodium falciparum Honduras 1 | - |
no. 1-CDC | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingomyelin + H2O | - |
Plasmodium falciparum | N-acylsphingosine + choline phosphate | - |
? | |
sphingomyelin + H2O | - |
Plasmodium falciparum Honduras 1 | N-acylsphingosine + choline phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
neutral sphingomyelinase | - |
Plasmodium falciparum |
SMase | - |
Plasmodium falciparum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | 8 | - |
Plasmodium falciparum |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5.5 | 9 | less than 5% of maximal activity at pH 5.5 and pH 9.0, respectively | Plasmodium falciparum |