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Literature summary for 3.1.4.12 extracted from

  • Hanada, K.; Mitamura, T.; Fukasawa, M.; Magistrado, P.A.; Horii, T.; Nishijima, M.
    Neutral sphingomyelinase activity dependent on Mg2+ and anionic phospholipids in the intraerythrocytic malaria parasite Plasmodium falciparum (2000), Biochem. J., 346, 671-677.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
cardiolipin anionic phospholipids required for activity, maximal activation at 1 mM, 21% of activation with phosphatidylserine Plasmodium falciparum
phosphatidic acid anionic phospholipids required for activity, maximal activation at 1 mM, 33% of activation with phosphatidylserine Plasmodium falciparum
phosphatidylglycerol anionic phospholipids required for activity, maximal activation at 1 mM, 79% of activation with phosphatidylserine Plasmodium falciparum
phosphatidylinositol anionic phospholipids required for activity, maximal activation at 1 mM, 53% of activation with phosphatidylserine Plasmodium falciparum
phosphatidylserine anionic phospholipids required for activity, maximal activation at 1 mM Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
scyphostatin 0.005 mM, 50% inhibition, complete inhibition at 0.033 mM Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1
-
sphingomyelin 37°C, pH 7.5 Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Plasmodium falciparum 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required for activity, half-maximal activation at 1 mM Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingomyelin + H2O Plasmodium falciparum
-
N-acylsphingosine + choline phosphate
-
?
sphingomyelin + H2O Plasmodium falciparum Honduras 1
-
N-acylsphingosine + choline phosphate
-
?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
no. 1-CDC
-
Plasmodium falciparum Honduras 1
-
no. 1-CDC
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O
-
Plasmodium falciparum N-acylsphingosine + choline phosphate
-
?
sphingomyelin + H2O
-
Plasmodium falciparum Honduras 1 N-acylsphingosine + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
neutral sphingomyelinase
-
Plasmodium falciparum
SMase
-
Plasmodium falciparum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 8
-
Plasmodium falciparum

pH Range

pH Minimum pH Maximum Comment Organism
5.5 9 less than 5% of maximal activity at pH 5.5 and pH 9.0, respectively Plasmodium falciparum