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Literature summary for 3.1.4.12 extracted from

  • Tepper, A.D.; Ruurs, P.; Borst, J.; van Blitterswijk, W.J.
    Effect of overexpression of a neutral sphingomyelinase on CD95-induced ceramide production and apoptosis (2001), Biochem. Biophys. Res. Commun., 280, 634-639.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS7 and Jurkat T cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
E49A no activity Homo sapiens
H272A no activity Homo sapiens
N180A no activity Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
x * 45000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingomyelin + H2O Homo sapiens
-
N-acylsphingosine + choline phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O60906
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O
-
Homo sapiens N-acylsphingosine + choline phosphate
-
?

Subunits

Subunits Comment Organism
? x * 45000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
neutral sphingomyelinase
-
Homo sapiens
nSMase1
-
Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
additional information
-
neutral pH required for activity Homo sapiens