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Literature summary for 3.1.4.12 extracted from

  • Lister, M.D.; Crawford-Redick, C.L.; Loomis, C.R.
    Characterization of the neutral pH-optimum sphingomyelinase from rat brain: inhibition by copper II and ganglioside GM3 (1993), Biochim. Biophys. Acta, 1165, 314-320.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
1-alpha,25-dihydroxyvitamin D3
-
Rattus norvegicus
EGTA Cu2+ not inhibitory when EGTA added prior Rattus norvegicus
phosphatidylserine
-
Rattus norvegicus
Triton X-100
-
Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Al3+
-
Rattus norvegicus
Cu2+
-
Rattus norvegicus
Fe3+
-
Rattus norvegicus
gangliosides particularly monogangilosides Rattus norvegicus
additional information
-
Rattus norvegicus
Zn2+
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
60 90 sphingomyelin
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Rattus norvegicus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial, 2fold Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
different assay conditions, substrates etc. Rattus norvegicus

Storage Stability

Storage Stability Organism
-80°C, several months Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
Rattus norvegicus