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Literature summary for 3.1.4.12 extracted from

  • Barnholz, Y.; Roitman, A.; Gatt, S.
    Enzymatic hydrolysis of sphingolipids. II. Hydrolysis of sphingomyelin by an enzyme from rat brain (1966), J. Biol. Chem., 241, 3731-3737.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cholate
-
Rattus norvegicus
Cutsum
-
Rattus norvegicus
Detergents activation Rattus norvegicus
ethanol
-
Rattus norvegicus
taurocholate
-
Rattus norvegicus
Triton X-100
-
Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
ceramide
-
Rattus norvegicus
cetyltrimethylammonium bromide
-
Rattus norvegicus
fatty acids
-
Rattus norvegicus
lecithin
-
Rattus norvegicus
phosphatidylinositol
-
Rattus norvegicus
phosphatidylserine
-
Rattus norvegicus
sphingosine
-
Rattus norvegicus
taurocholate in presence of Triton X-100 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.13
-
sphingomyelin
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingomyelin + H2O Rattus norvegicus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
18fold Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Storage Stability

Storage Stability Organism
-20°C, 250 mM sucrose, 20 mM Tris buffer, several weeks Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O D-erythrosphingosine or dihydroxysphingosine configuration of sphingomyelin results in a 3-5fold faster hydrolysis in comparison to a D-threo or L-erythro configuration Rattus norvegicus N-acylsphingosine + choline phosphate
-
ir
sphingomyelin + H2O
-
Rattus norvegicus ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
-
Rattus norvegicus