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Literature summary for 3.1.4.12 extracted from

  • Kanfer, J.N.; Young, O.M.; Shapiro, D.; Brady, R.O.
    The metabolism of sphingomyelin. I. Purification and properties of a sphingomyelin-cleaving enzyme from rat liver tissue (1966), J. Biol. Chem., 241, 1081-1084.
    View publication on PubMed
Search for more literature for 3.1.4.12

Activating Compound

Activating Compound Comment Organism Structure
sodium deoxycholate
-
 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
p-hydroxymercuribenzoate slight Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.18
-
 sphingomyelin
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingomyelin + H2O Rattus norvegicus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial, 60fold Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
intestine
-
 Rattus norvegicus
-
kidney
-
 Rattus norvegicus
-
liver distribution in tissues, liver most active source Rattus norvegicus
-
lung
-
 Rattus norvegicus
-
spleen
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 different assay conditions, substrates etc. Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O
-
 Rattus norvegicus N-acylsphingosine + choline phosphate
-
 ?
sphingomyelin + H2O
-
 Rattus norvegicus ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
-
 Rattus norvegicus