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Literature summary for 3.1.4.12 extracted from

  • Hostetler, K.Y.; Yazaki, P.J.
    The subcellular localization of neutral sphingomyelinase in rat liver (1979), J. Lipid Res., 20, 456-463.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5'-AMP lysosomes Rattus norvegicus
AMP lysosomes Rattus norvegicus
Hg2+ plasma membrane and microsomes Rattus norvegicus
Mg2+ lysosomal enzyme, inhibition at below pH 4.8 Rattus norvegicus
n-butanol plasma membrane Rattus norvegicus
p-chloromercuribenzoate plasma membrane and microsomes Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.62
-
sphingomyelin microsomes Rattus norvegicus
1.2
-
sphingomyelin lysosomes, at 0.5 mM sphingomyelin Rattus norvegicus
13
-
sphingomyelin lysosomes, at 2 mM sphingomyelin Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-
lysosome
-
Rattus norvegicus 5764
-
membrane
-
Rattus norvegicus 16020
-
microsome
-
Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ lysosomal enzyme, stimulation at pH 5-7.5 Rattus norvegicus
Co2+ lysosomal enzyme, stimulation at pH 5-7.5 Rattus norvegicus
Mg2+ lysosomal enzyme, stimulation at pH 5-7.5 Rattus norvegicus
Mg2+ activation of plasma membrane and microsomal enzyme Rattus norvegicus
Mn2+ lysosomal enzyme, stimulation at pH 5-7.5 Rattus norvegicus
Mn2+ activation of plasma membrane and microsomal enzyme Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingomyelin + H2O Rattus norvegicus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
different assay conditions, substrates etc. Rattus norvegicus
additional information
-
microsomes, lysosomes and plasma membrane Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O
-
Rattus norvegicus N-acylsphingosine + choline phosphate
-
?
sphingomyelin + H2O
-
Rattus norvegicus ?
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
55
-
plasma membrane and microsomes, 10 min, 15% activity, lysosomes, 10 min, 78% activity Rattus norvegicus
70
-
denaturation Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.4 4.8 in lysosomes Rattus norvegicus
7 7.2 plasma membranes Rattus norvegicus
7.2
-
microsomes Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
5 8.5 plasma membranes Rattus norvegicus
5 7.5 lysosomal enzyme stimulated by different divalent cations Rattus norvegicus