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Literature summary for 3.1.4.12 extracted from

  • Tomita, M.; Taguchi, R.; Ikezawa, H.
    Molecular properties and kinetic studies on sphingomyelinase of Bacillus cereus (1982), Biochim. Biophys. Acta, 704, 90-99.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Detergents
-
Bacillus cereus
sodium deoxycholate
-
Bacillus cereus
Triton X-100 activation with sphingomyelin Bacillus cereus

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ when sphingomyelin as substrate with Triton X-100 is used, competitive inhibitor against Mg2+ Bacillus cereus
cetyltrimethylammonium bromide
-
Bacillus cereus
EDTA
-
Bacillus cereus
Triton X-100 slight inhibition with 2-hexadecynoylamino-4-nitrophenylphosphorylcholine Bacillus cereus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.034
-
2-n-hexadecanoylamino-4-nitrophenylphosphorylcholine in presence of Mg2+ Bacillus cereus
0.038
-
sphingomyelin in presence of Mg2+ and Triton X-100 Bacillus cereus
0.17
-
sphingomyelin in presence of Mg2+ and sodium deoxycholate Bacillus cereus
0.174
-
hexadecanoyl-p-nitrophenyl phosphorylcholine
-
Bacillus cereus
0.405
-
sphingomyelin in presence of Triton X-100 Bacillus cereus
0.565
-
sphingomyelin in presence of sodium deoxycholate Bacillus cereus
11.6
-
4-nitrophenyl phosphorylcholine
-
Bacillus cereus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ slight activation when water-soluble substrates are used Bacillus cereus
Mg2+
-
Bacillus cereus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
23300
-
sedimentation equilibrium centrifugation Bacillus cereus
41000
-
x * 41000, SDS-PAGE Bacillus cereus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingomyelin + H2O Bacillus cereus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Bacillus cereus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
2200fold Bacillus cereus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-n-hexadecanoylamino-4-nitrophenylphosphorylcholine + H2O
-
Bacillus cereus 2-n-hexadecanoylamino-4-nitrophenol + choline phosphate
-
?
4-nitrophenyl phosphorylcholine + H2O
-
Bacillus cereus 4-nitrophenol + phosphorylcholine
-
?
hexadecanoyl-p-nitrophenylphosphorylcholine + H2O
-
Bacillus cereus hexadecanoyl-p-nitrophenol + choline phosphate
-
?
lysophosphatidylcholine + H2O
-
Bacillus cereus 1-acylglycerol + choline phosphate
-
?
p-nitrophenylphosphorylcholine + H2O
-
Bacillus cereus choline phosphate + p-nitrophenol
-
?
sphingomyelin + H2O
-
Bacillus cereus ?
-
?

Subunits

Subunits Comment Organism
? x * 41000, SDS-PAGE Bacillus cereus