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Literature summary for 3.1.4.12 extracted from

  • Watanabe, K.; Sakuragawa, N.; Arima, M.; Satoyoshi, E.
    Partial purification and properties of acid sphingomyelinase from rat liver (1983), J. Lipid Res., 24, 596-603.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Detergents
-
Rattus norvegicus
Triton X-100 activation at very low concentrations Rattus norvegicus

General Stability

General Stability Organism
glycerol, stabilization Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Chloroquine diphosphate salt, 50% inhibition at 5 mM Rattus norvegicus
dithiothreitol
-
Rattus norvegicus
phosphate
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.027
-
2n-hexadecanoylamino-4-nitrophenylphosphorylcholine
-
Rattus norvegicus
0.079
-
sphingomyelin
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Rattus norvegicus 5764
-
mitochondrion
-
Rattus norvegicus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
1 * 45600 + 1 * 44500 + 1 * 40000, SDS-PAGE Rattus norvegicus
44500
-
1 * 45600 + 1 * 44500 + 1 * 40000, SDS-PAGE Rattus norvegicus
45600
-
1 * 45600 + 1 * 44500 + 1 * 40000, SDS-PAGE Rattus norvegicus
220000
-
gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingomyelin + H2O Rattus norvegicus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
5200fold Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
different assay conditions, substrates etc. Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-n-hexadecanoylamino-4-nitrophenylphosphorylcholine + H2O
-
Rattus norvegicus 2-n-hexadecanoylamino-4-nitrophenol + choline phosphate
-
?
bis(4-methylumbelliferyl)-phosphate + H2O poor substrate Rattus norvegicus ?
-
?
bis-p-nitrophenyl phosphate + H2O poor substrate Rattus norvegicus ?
-
?
hexadecanoyl-p-nitrophenylphosphorylcholine + H2O
-
Rattus norvegicus hexadecanoyl-p-nitrophenol + choline phosphate
-
?
sphingomyelin + H2O
-
Rattus norvegicus ?
-
?

Subunits

Subunits Comment Organism
trimer 1 * 45600 + 1 * 44500 + 1 * 40000, SDS-PAGE Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
-
Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
5
-
Chloroquine diphosphate salt Rattus norvegicus