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Literature summary for 3.1.4.12 extracted from

  • Quintern, L.E.; Weitz, G.; Nehrkorn, H.; Tager, J.M.; Schram, A.W.; Sandhoff, K.
    Acid sphingomyelinase from human urine: purification and characterization (1987), Biochim. Biophys. Acta, 922, 323-336.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ceramide
-
Homo sapiens
Diacylglycerols
-
Homo sapiens
Lipids saturated and unsaturated fatty acids Homo sapiens
monoacylglycerols
-
Homo sapiens
triacylglycerols
-
Homo sapiens
Tripalmitoylglycerol
-
Homo sapiens

General Stability

General Stability Organism
detergents, e.g. Nonidet P-40, stabilization Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2'-AMP mixture with 3'-AMP Homo sapiens
3'-AMP mixture with 2'-AMP Homo sapiens
3-[benzyl(tert-butyl)amino]-1-(4-nitrophenyl)propan-1-one
-
Homo sapiens
5'-AMP
-
Homo sapiens
adenine-9-beta-D-arabinofuranoside 5'-monophosphate
-
Homo sapiens
adenosine 3',5'-diphosphate
-
Homo sapiens
adenosine 5'-monophosphate periodate-oxidized and an isomer with arabinose instead of ribose as sugar component Homo sapiens
Adenosine 5'-O-thiomonosulfate
-
Homo sapiens
adenosine 5'-phosphosulfate
-
Homo sapiens
dithioerythritol
-
Homo sapiens
phosphatidylinositol
-
Homo sapiens
phosphatidylinositol 4',5'-bisphosphate
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.069
-
sphingomyelin
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
x * 70000, 2 or 4 subunits, SDS-PAGE Homo sapiens
200000
-
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingomyelin + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
22990fold Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
urine
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
41
-
-
Homo sapiens

Storage Stability

Storage Stability Organism
4°C, 50% loss of activity after 3-5 months Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylcholine + H2O in the presence of 0.08% sodium taurodeoxycholate Homo sapiens diacylglycerol + choline phosphate
-
?
phosphatidylethanolamine + H2O in the presence of 0.08% sodium taurodeoxycholate Homo sapiens diacylglycerol + phosphorylethanolamine
-
?
phosphatidylglycerol + H2O in the presence of 0.08% sodium taurodeoxycholate Homo sapiens diacylglycerol + glycerolphosphate
-
?
phosphatidylglycerol + H2O in the absence of detergents an in the presence of 0.05% Nonidet P-40 Homo sapiens diacylglycerol + glycerolphosphate
-
?
sphingomyelin + H2O
-
Homo sapiens N-acylsphingosine + choline phosphate
-
?
sphingomyelin + H2O
-
Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
? x * 70000, 2 or 4 subunits, SDS-PAGE Homo sapiens

pH Stability

pH Stability pH Stability Maximum Comment Organism
7.2
-
highest stability Homo sapiens