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Literature summary for 3.1.4.11 extracted from

  • Seo, J.B.; Jung, S.R.; Huang, W.; Zhang, Q.; Koh, D.S.
    Charge shielding of PIP2 by cations regulates enzyme activity of phospholipase C (2015), PLoS ONE, 10, e0144432 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.11

Activating Compound

Activating Compound Comment Organism Structure
additional information spermine does not stimulate the activity of isoform PLCbeta1 Homo sapiens
spermine spermine potentiates the activity of isoform PLCgamma1 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Ba2+
-
 Homo sapiens
Mg2+
-
 Homo sapiens
neomycin neomycin does not inhibit the enzyme activity completely Homo sapiens
putrescine putrescine is less efficient than divalent cations in reducing isoform PLCbeta1 activity Homo sapiens
spermidine
-
 Homo sapiens
spermine
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ stimulates activity of isoform PLCbeta1 with saturation at 0.02 mM Ca2+ Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Homo sapiens
-
 1D-myo-inositol 1,4,5-triphosphate + diacylglycerol
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
 Homo sapiens 1D-myo-inositol 1,4,5-triphosphate + diacylglycerol
-
 ?
1D-myo-inositol 1,4,5-trisphosphate fluorescent derivative WH-15 + H2O
-
 Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + quinomethide + 6-aminoquinoline + ?
-
 ir

Synonyms

Synonyms Comment Organism
phospholipase C
-
 Homo sapiens
PLCbeta1 isoform Homo sapiens
PLCdelta1 isoform Homo sapiens
PLCgamma1 isoform Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.006
-
 isoform PLCdelta1, at pH 7.3 and 25°C Homo sapiens neomycin
0.011
-
 isoform PLCbeta1, at pH 7.3 and 25°C Homo sapiens neomycin
0.024
-
 isoform PLCgamma1, at pH 7.3 and 25°C Homo sapiens neomycin
0.4
-
 isoform PLCbeta1, at pH 7.3 and 25°C Homo sapiens spermine
1.7
-
 isoform PLCdelta1, at pH 7.3 and 25°C Homo sapiens spermine
4
-
 isoform PLCgamma1, at pH 7.3 and 25°C Homo sapiens spermine