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Literature summary for 3.1.4.11 extracted from

  • Di Raimo, T.; Leopizzi, M.; Mangino, G.; Rocca, C.D.; Businaro, R.; Longo, L.; Lo Vasco, V.R.
    Different expression and subcellular localization of phosphoinositide-specific phospholipase C enzymes in differently polarized macrophages (2016), J. Cell Commun. Signal., 10, 283-293 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.11

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
Golgi apparatus
-
 Homo sapiens 5794
-
nucleus
-
 Homo sapiens 5634
-
vesicle
-
 Homo sapiens 31982
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Homo sapiens
-
 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage M1, M2 and unpolarized M0 macrophages Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
 Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?

Synonyms

Synonyms Comment Organism
phosphoinositide-specific phospholipase C
-
 Homo sapiens
PLCbeta1 isoform Homo sapiens
PLCbeta2 isoform Homo sapiens
PLCbeta3 isoform Homo sapiens
PLCbeta4 isoform Homo sapiens
PLCdelta1 isoform Homo sapiens
PLCdelta3 isoform Homo sapiens
PLCdelta4 isoform Homo sapiens
PLCepsilon isoform Homo sapiens
PLCeta1 isoform Homo sapiens
PLCeta2 isoform Homo sapiens
PLCgamma1 isoform Homo sapiens
PLCgamma2 isoform Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme plays a complex role in macrophages during inflammation and probably also during polarization Homo sapiens