Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of PLCbeta1, 2, 3, and 4 gene-deficient KO mice and analysis of the resulting phenotypes, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | PLC is a soluble protein that is localized mainly in the cytosol and is translocated to the plasma membrane, where it hydrolyzes PI(4,5)P2 in response to cell activation | Mus musculus | 5829 | - |
cytosol | PLC is a soluble protein that is localized mainly in the cytosol and is translocated to the plasma membrane, where it hydrolyzes PI(4,5)P2 in response to cell activation | Homo sapiens | 5829 | - |
cytosol | PLC is a soluble protein that is localized mainly in the cytosol and is translocated to the plasma membrane, where it hydrolyzes PI(4,5)P2 in response to cell activation | Rattus norvegicus | 5829 | - |
plasma membrane | PLC is a soluble protein that is localized mainly in the cytosol and is translocated to the plasma membrane, where it hydrolyzes PI(4,5)P2 in response to cell activation. Membrane association of PLCdelta1 is mediated by its PH domain | Mus musculus | 5886 | - |
plasma membrane | PLC is a soluble protein that is localized mainly in the cytosol and is translocated to the plasma membrane, where it hydrolyzes PI(4,5)P2 in response to cell activation. Membrane association of PLCdelta1 is mediated by its PH domain | Homo sapiens | 5886 | - |
plasma membrane | PLC is a soluble protein that is localized mainly in the cytosol and is translocated to the plasma membrane, where it hydrolyzes PI(4,5)P2 in response to cell activation. Membrane association of PLCdelta1 is mediated by its PH domain | Rattus norvegicus | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | all PLC isozymes require calcium for their activity, the PLCdelta-type is one of the most sensitive to calcium, suggesting that the activity of the PLCdelta-type may be regulated by calcium. PLCzeta is extremely sensitive to the calcium concentration | Mus musculus | |
Ca2+ | all PLC isozymes require calcium for their activity, the PLCdelta-type is one of the most sensitive to calcium, suggesting that the activity of the PLCdelta-type may be regulated by calcium. PLCzeta is extremely sensitive to the calcium concentration | Homo sapiens | |
Ca2+ | all PLC isozymes require calcium for their activity, the PLCdelta-type is one of the most sensitive to calcium, suggesting that the activity of the PLCdelta-type may be regulated by calcium. PLCzeta is extremely sensitive to the calcium concentration | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | Mus musculus | - |
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | products are two second messengers | ? | |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | Homo sapiens | - |
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | products are two second messengers | ? | |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | Rattus norvegicus | - |
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | products are two second messengers | ? | |
additional information | Mus musculus | PLCepsilon exhibits activity as RasGEF toward Rap1, but not to Ras, Rap2A or Rho | ? | - |
? | |
additional information | Homo sapiens | PLCepsilon exhibits activity as RasGEF toward Rap1, but not to Ras, Rap2A or Rho | ? | - |
? | |
additional information | Rattus norvegicus | PLCepsilon exhibits activity as RasGEF toward Rap1, but not to Ras, Rap2A or Rho | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiac myocyte | - |
Mus musculus | - |
cardiac myocyte | - |
Homo sapiens | - |
cardiac myocyte | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Mus musculus | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Homo sapiens | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Rattus norvegicus | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Mus musculus | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | products are two second messengers | ? | |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Homo sapiens | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | products are two second messengers | ? | |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Rattus norvegicus | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | products are two second messengers | ? | |
additional information | PLCepsilon exhibits activity as RasGEF toward Rap1, but not to Ras, Rap2A or Rho | Mus musculus | ? | - |
? | |
additional information | PLCepsilon exhibits activity as RasGEF toward Rap1, but not to Ras, Rap2A or Rho | Homo sapiens | ? | - |
? | |
additional information | PLCepsilon exhibits activity as RasGEF toward Rap1, but not to Ras, Rap2A or Rho | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PLC | - |
Mus musculus |
PLC | - |
Homo sapiens |
PLC | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | PLC isozymes are involved in several diseases, detailed overview | Mus musculus |
malfunction | PLC isozymes are involved in several diseases, detailed overview | Homo sapiens |
additional information | co-expression of PLCeta2 and Gbetagamma protein results in higher PLC activity | Mus musculus |
additional information | co-expression of PLCeta2 and Gbetagamma protein results in higher PLC activity | Homo sapiens |
additional information | co-expression of PLCeta2 and Gbetagamma protein results in higher PLC activity | Rattus norvegicus |
physiological function | PLC is involved in the regulation of proliferation, differentiation, and tumor formation, the switch between proliferation and differentiation is caused by PLCs. PLC regulates the spatio-temporal balance of phosphoinositides. Calcium mobilization is an essential cellular function of PLC. PLCzeta and PLCdelta4 are involved in the calcium increase in the first step of fertilization. PLCbeta- and PLCeta-type are involved in neuronal function. PLCdelta1 regulates skin homeostasis. The PLCepsilon is an effector of Ras protein, both upstream and downstream, and its activity is regulated by Ras in a GTP-dependent manner. PLC is a soluble protein that is localized mainly in the cytosol and is translocated to the plasma membrane, where it hydrolyzes PI(4,5)P2 in response to cell activation. Thus, targeting of PLC to the plasma membrane is a critical event for signal transduction. Association with heterotrimeric G-proteins of the Gq family induces the activity of beta-type PLCs. gamma-Type isozymes are regulated primarily by receptor and cytosolic tyrosine kinases, mechanisms, overview | Mus musculus |
physiological function | PLC is involved in the regulation of proliferation, differentiation, and tumor formation, the switch between proliferation and differentiation is caused by PLCs. PLC regulates the spatio-temporal balance of phosphoinositides. Calcium mobilization is an essential cellular function of PLC. PLCzeta and PLCdelta4 are involved in the calcium increase in the first step of fertilization. PLCbeta- and PLCeta-type are involved in neuronal function. PLCdelta1 regulates skin homeostasis. The PLCepsilon is an effector of Ras protein, both upstream and downstream, and its activity is regulated by Ras in a GTP-dependent manner. PLC is a soluble protein that is localized mainly in the cytosol and is translocated to the plasma membrane, where it hydrolyzes PI(4,5)P2 in response to cell activation. Thus, targeting of PLC to the plasma membrane is a critical event for signal transduction. Association with heterotrimeric G-proteins of the Gq family induces the activity of beta-type PLCs. gamma-Type isozymes are regulated primarily by receptor and cytosolic tyrosine kinases, mechanisms, overview | Homo sapiens |
physiological function | PLC is involved in the regulation of proliferation, differentiation, and tumor formation, the switch between proliferation and differentiation is caused by PLCs. PLC regulates the spatio-temporal balance of phosphoinositides. Calcium mobilization is an essential cellular function of PLC. PLCzeta and PLCdelta4 are involved in the calcium increase in the first step of fertilization. PLCbeta- and PLCeta-type are involved in neuronal function. PLCdelta1 regulates skin homeostasis. The PLCepsilon is an effector of Ras protein, both upstream and downstream, and its activity is regulated by Ras in a GTP-dependent manner. PLC is a soluble protein that is localized mainly in the cytosol and is translocated to the plasma membrane, where it hydrolyzes PI(4,5)P2 in response to cell activation. Thus, targeting of PLC to the plasma membrane is a critical event for signal transduction. Association with heterotrimeric G-proteins of the Gq family induces the activity of beta-type PLCs. gamma-Type isozymes are regulated primarily by receptor and cytosolic tyrosine kinases, mechanisms, overview | Rattus norvegicus |