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Literature summary for 3.1.4.11 extracted from
- Multiple roles for Plasmodium berghei phosphoinositide-specific phospholipase C in regulating gametocyte activation and differentiation (2011), Cell. Microbiol., 13, 955-966.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| xanthurenic acid | triggers the hydrolysis of phosphoinositide by PI-PLC in gametocytes | Plasmodium berghei |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| U73122 | direct activation of PI-PLC though Ca2+ may bypass inhibition by U73122, PI-PLC activity is not sensitive to U73122 when activated by the Ca2+ ionophore A23187. Unphysiologically high Ca2+ levels can overcome PI-PLC inhibition by U73122 | Plasmodium berghei | |
| U73343 | - |
Plasmodium berghei | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | unphysiologically high Ca2+ levels can overcome PI-PLC inhibition by U73122 | Plasmodium berghei | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Plasmodium berghei | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| gametocyte | - |
Plasmodium berghei | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
analysis of PI-PLC product levels upon gametocyte activation, overview | Plasmodium berghei |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phosphoinositide-specific phospholipase C | - |
Plasmodium berghei |
| PI-PLC | - |
Plasmodium berghei |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.003 | - |
pH and temperature not specified in the publication | Plasmodium berghei | U73122 | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme is involved in calcium-dependent signalling cascades controlling the life cycle of malaria parasites. Synchronized development of Plasmodium berghei gametocytes relies on rapid calcium release from internal stores within 10 s of gametocytes being exposed to mosquito-derived xanthurenic acid, which triggers the enzyme. Requirement for PI-PLC beyond the early mobilization of calcium, with a complex interdependency of Ca2+ and PI-PLC activity, with PI-PLC being essential throughout gamete formation, possibly explaining the irreversibility of this process | Plasmodium berghei |
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