Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | Streptomyces antibioticus | saPLC1 employs a unique catalytic mechanism whereby the cleavage of phosphatidylinositol into inositol 1-phosphate occurs via a trans cyclization mechanism involving formation of inositol 1,6-cyclic phosphate as an intermediate | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces antibioticus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | kinetic and catalytic reaction mechanism, overview | Streptomyces antibioticus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Streptomyces antibioticus | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | saPLC1 employs a unique catalytic mechanism whereby the cleavage of phosphatidylinositol into inositol 1-phosphate occurs via a trans cyclization mechanism involving formation of inositol 1,6-cyclic phosphate as an intermediate | Streptomyces antibioticus | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
additional information | synthesis of a short-chain (dihexanoyl) analogues of phosphatidylinositol, which exist as monomers at the concentrations used for the kinetic measurements, the cleavage proceeds with the release of the cyclic phosphorothioate | Streptomyces antibioticus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol-specific phospholipase C | - |
Streptomyces antibioticus |
PLC1 | - |
Streptomyces antibioticus |