Literature summary for 3.1.4.11 extracted from

Harita, Y.; Kurihara, H.; Kosako, H.; Tezuka, T.; Sekine, T.; Igarashi, T.; Ohsawa, I.; Ohta, S.; Hattori, S.
Phosphorylation of nephrin triggers Ca2+ signaling by recruitment and activation of phospholipase C-[gamma]1 (2009), J. Biol. Chem., 284, 8951-8962.

Search for more literature for 3.1.4.11

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	recruitment of PLC-gamma1 to nephrin activated PLC-gamma1, as detected by phosphorylation of PLC-gamma1 Tyr-783 and increase in inositol 1,4,5-trisphosphate level	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
additional information	PLC-gamma1 is bound to phosphorylated nephrin Tyr-1204, which induces translocation of PLC-gamma1 from cytoplasm to the CD8/Nephrin cluster on the plasma membrane	Homo sapiens	-	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P19174	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293T cell	-	Homo sapiens	-
kidney	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O	-	Homo sapiens	1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol	-	?

Synonyms

Synonyms	Comment	Organism
phospholipase C-gamma1	-	Homo sapiens
PLC-gamma1	phospho-nephrin-binding protein	Homo sapiens

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Release 2023.1 (January 2023)