Literature summary for 3.1.4.11 extracted from

Bertagnolo, V.; Benedusi, M.; Brugnoli, F.; Lanuti, P.; Marchisio, M.; Querzoli, P.; Capitani, S.
Phospholipase C-beta 2 promotes mitosis and migration of human breast cancer-derived cells (2007), Carcinogenesis, 28, 1638-1645.

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Application

Application	Comment	Organism
medicine	PLC-beta2 may constitute a molecular marker of breast tumor cells able to monitor the progression to invasive cancers and a target for novel therapeutic breast cancer strategies	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	PLC-beta2 may improve some malignant characteristics of tumor cells, like motility and invasion capability, but it fails to induce tumorigenesis in nontransformed breast-derived cells	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q00722	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	compared with the G0/G1 phases of the cell cycle, the cells in S/G2/M phases show high PLC-beta2 expressions that reach the greatest levels during the late mitotic stages. Phospholipase C-beta2 promotes mitosis and migration of human breast cancer-derived cells	Homo sapiens	-
MDA-MB-231 cell	compared with the G0/G1 phases of the cell cycle, the cells in S/G2/M phases show high PLC-b2 expressions that reach the greatest levels during the late mitotic stages. Phospholipase C-beta2 promotes mitosis and migration of human breast cancer-derived cells	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	PLC-beta2 may improve some malignant characteristics of tumor cells, like motility and invasion capability, but it fails to induce tumorigenesis in nontransformed breast-derived cells	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
phospholipase C-beta 2	-	Homo sapiens
PLC-beta2	-	Homo sapiens

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Release 2023.1 (January 2023)