Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.4.11 extracted from

  • Kim, Y.J.; Sekiya, F.; Poulin, B.; Bae, Y.S.; Rhee, S.G.
    Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2 (2004), Mol. Cell. Biol., 24, 9986-9999.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
Y1217F phosphorylation site mutant Homo sapiens
Y753F phosphorylation site mutant Homo sapiens
Y759F phosphorylation site mutant Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information LY294002 inhibits the BCR-induced PLC activation in Ramos cells in a dose-dependent manner Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens P16885
-
-
Mus musculus
-
-
-
Mus musculus Q8CIH5
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein PLC-gamma2 is phosphorylated on Y753, Y759, and Y1271 in response to engagement of the B-cell receptor in Ramos cells. In Ramos cells stimulated maximally with this receptor, the extent of phosphorylation of Y1217 is three times that of Y753 or of Y759. Stimulation of Jurkat cells or platelets via their immunoreceptors elicites phosphorylation of Y753 and Y759 but not that of Y1217. A basal level of phosphorylation of Y753 is apparent in unstimulated lymphocytes. The extent of phosphorylation of Y753 and Y759, but not that of Y1217 correlates with the lipase activity of PLC-gamma2. Btk is largely, but not completely, responsible for phosphorylation of Y753 and Y759, whereas phosphorylation of Y1217 is independent of Btk. Phosphorylation of Y1217 and that of Y753 and Y759 occurs on different PLC-gamma2 molecules Homo sapiens
phosphoprotein PLC-gamma2 is phosphorylated on Y753, Y759, and Y1271 in response to engagement of the B-cell receptor in spleenic cells. In spleenic cells stimulated maximally with this receptor, the extent of phosphorylation of Y1217 is three times that of Y753 or of Y759 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
Homo sapiens
-
JURKAT cell
-
Homo sapiens
-
Ramos cell
-
Homo sapiens
-
spleen
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
Mus musculus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
?

Synonyms

Synonyms Comment Organism
phospholipase C-gamma2
-
Mus musculus
phospholipase C-gamma2
-
Homo sapiens
PLC-gamma2
-
Mus musculus
PLC-gamma2
-
Homo sapiens