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Literature summary for 3.1.4.11 extracted from

  • Piechulek, T.; Rehlen, T.; Walliser, C.; Vatter, P.; Moepps, B.; Gierschik, P.
    Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases (2005), J. Biol. Chem., 280, 38923-38931.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in baculovirus-infected insect cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens wild-type Rac GTPase with guanosine 5'-(3-O-thio)triphosphate causes a marked stimulation of PLCgamma2 but has no effect on the activity of PLCgamma1. The mechanism of PLCgamma2 activation by Rac GTPase involves neither protein phosphorylation nor PI3K-mediated generation of phosphatidylinositol 3,4,5-trisphosphate ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
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Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
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?
additional information wild-type Rac GTPase with guanosine 5'-(3-O-thio)triphosphate causes a marked stimulation of PLCgamma2 but has no effect on the activity of PLCgamma1. The mechanism of PLCgamma2 activation by Rac GTPase involves neither protein phosphorylation nor PI3K-mediated generation of phosphatidylinositol 3,4,5-trisphosphate Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
phospholipase C-gamma2
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Homo sapiens