Literature summary for 3.1.4.11 extracted from

Seifert, J.P.; Wing, M.R.; Snyder, J.T.; Gershburg, S.; Sondek, J.; Harden, T.K.
RhoA activates purified phospholipase C-epsilon by a guanine nucleotide-dependent mechanism (2004), J. Biol. Chem., 279, 47992-47997.

Search for more literature for 3.1.4.11

Activating Compound

Activating Compound	Comment	Organism	Structure
RhoA	PLC-epsilon is a direct downstream efector for RhoA. RhA-dependent activation of PLC-epsilon depends on a unique insert within the catalytic core of the phospholipase	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.006	-	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate	25°C, pH 7.4	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O	-	Rattus norvegicus	1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol	-	?
phosphatidylinositol 4-phosphate + H2O	-	Rattus norvegicus	1D-myo-inositol 4,5-bisphosphate + diacylglycerol	-	?

Synonyms

Synonyms	Comment	Organism
phospholipase C-epsilon	-	Rattus norvegicus
PLC-epsilon	-	Rattus norvegicus

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Release 2023.1 (January 2023)