Activating Compound | Comment | Organism | Structure |
---|---|---|---|
insulin-like growth factor 1 | stimulates nuclear PLCbeta1, through translocation of MAP kinase to the nucleus | Mus musculus | |
MAP kinase | phosphorylates and activates nuclear PLCbeta1 | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | all the four isoenzymes of the beta family are detectable in nuclei, beta1, beta2, beta3 and beta4, but not PLCgamma and PLCdelta, membrane deprived nuclei possess a higher amount of PLCs, beta isoenzymes are localized in the inner nuclear compartment and not in the nuclear envelope | Mus musculus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | Mus musculus | PLCbeta1 is involved in nuclear inositol lipid signaling | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
PLCbeta1 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | increased phosphorylation of nuclear PLCbeta1, due to nuclear translocation of MAP kinase, is required for the activation of the nuclear inositol lipid cycle in 3T3 cells treated with insulin-like growth factor 1 | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
NIH-3T3 cell | fibroblasts, treated with insulin-like growth factor 1 | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
PLC beta isoenzymes, activities in membrane deprived and intact nuclei | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Mus musculus | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | PLCbeta1 is involved in nuclear inositol lipid signaling | Mus musculus | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | ten mammalian isoenzymes, grouped into three families: PLCbeta, PLCgamma and PLCdelta | Mus musculus |