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Literature summary for 3.1.4.11 extracted from

  • Shute, J.K.; Smith, M.E.
    Soluble phosphatidylinositol phosphodiesterase in normal and denervated fast and slow muscles of the rat (1984), Biochem. J., 222, 299-305.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
deoxycholate required for activity with membrane-bound phosphatidylinositol, slight stimulation with isolated phosphatidylinositol Rattus norvegicus
oleic acid causes a marked stimulation of the enzyme activity when the membrane-bound substrate is used Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ stimulates the activity and can not be replaced by MnCl2, MgCl2 or ZnCl2 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
female Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle prepared from rat slow (soleus) and fast (extensor digitorum longus) muscles Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
enzyme specific activity is higher in cytosol prepared from soleus muscle than in that from extensor digitorum longus muscle Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylinositol + H2O enzyme hydrolyses both membrane-bound and extracted phosphatidylinositol Rattus norvegicus 1D-myo-inositol 1-phosphate + diacylglycerol in vitro myo-inositol 1,2-cyclic phosphate, myo-inositol 1-phosphate, and glycerophosphoinositol in the molar proportions approx. 2:1:1 ?

Synonyms

Synonyms Comment Organism
phosphatidylinositol phosphodiesterase
-
Rattus norvegicus
PtdIns phosphodiesterase
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
two pH optima are apparent, at pH 5.5 and pH 7.4 Rattus norvegicus
7.4
-
two pH optima are apparent, at pH 5.5 and pH 7.4 Rattus norvegicus