Activating Compound | Comment | Organism | Structure |
---|---|---|---|
arachidonic acid | enhances hyrolysis of phosphatidylinositol 4,5-diphosphate, membrane bound enzyme and cytosolic enzyme | Mus musculus | |
diacylglycerol | enhances hyrolysis of phosphatidylinositol 4,5-diphosphate, membrane bound enzyme and cytosolic enzyme | Mus musculus | |
phosphatidic acid | enhances hyrolysis of phosphatidylinositol 4,5-diphosphate, membrane bound enzyme and cytosolic enzyme | Mus musculus | |
phosphatidylcholine | enhances hyrolysis of phosphatidylinositol 4,5-diphosphate, membrane bound enzyme | Mus musculus | |
phosphatidylethanolamine | enhances hyrolysis of phosphatidylinositol 4,5-diphosphate, membrane bound enzyme and cytosolic enzyme | Mus musculus | |
phosphatidylserine | enhances hyrolysis of phosphatidylinositol 4,5-diphosphate, membrane bound enzyme | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
membrane | bound to | Mus musculus | 16020 | - |
microsome | - |
Mus musculus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
68000 | 70000 | membrane-bound enzyme, in presence of sodium cholate, gel filtration | Mus musculus |
71000 | 72000 | cytosolic enzyme, in presence of sodium deoxycholate, gel filtration | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partial | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
thymocyte | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.114 | - |
membrane-bound enzyme | Mus musculus |
0.235 | - |
cytosolic enzyme | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylinositol + H2O | at neutral pH and low Ca2+ concentration the membrane bound enzyme hydrolyzes phosphatidylinositol 4,5-diphosphate in preference to phosphatidylinositol | Mus musculus | ? | - |
? | |
phosphatidylinositol 4,5-bisphosphate + H2O | membrane-bound enzyme hydrolyzes phosphatidylinositol 4,5-diphosphate in preference to phosphatidylinositol | Mus musculus | D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
hydrolysis of phosphatidylinositol, membrane bound enzyme and cytosolic enzyme | Mus musculus |
7.5 | - |
hyrolysis of phosphatidylinositol 4,5-diphosphate, membrane bound enzyme and cytosolic enzyme | Mus musculus |