Literature summary for 3.1.4.1 extracted from

Borda, M.A.; Palmitelli, M.; Veron, G.; Gonzalez-Cid, M.; de Campos Nebel, M.
Tyrosyl-DNA-phosphodiesterase I (TDP1) participates in the removal and repair of stabilized-Top2alpha cleavage complexes in human cells (2015), Mutat. Res., 781, 37-48 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NUW8	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
TDP1	-	Homo sapiens
tyrosyl-DNA-phosphodiesterase I	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	enzyme knockdown cells are hypersensitive to etoposide. Late, but not early double-stranded break signaling response is altered in human cells lacking the enzyme. Enzyme knockdown impairs the repair of topoisomerase II-induced DNA double-stranded breaks	Homo sapiens
physiological function	tyrosyl-DNA-phosphodiesterase 1 is a DNA repair enzyme that removes irreversible protein-linked 3'-DNA complexes, 3'-phosphoglycolates, alkylation damage-induced DNA breaks, and 3'-deoxyribose nucleosides. The enzyme plays an active role in the repair of topoisomerase II-induced DNA damage	Homo sapiens

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Release 2023.1 (January 2023)