Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | processing by the proteasome is required for TDP1 cleavage in vivo | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | tyrosyl-DNA phosphodiesterase 1 catalyses the hydrolysis of phosphodiester linkages between a DNA 3' phosphate and a tyrosine residue as well as a variety of other DNA 3 substituents, the enzyme shows affinity for the substrate increased as the DNA length | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | tyrosyl-DNA phosphodiesterase 1 catalyses the hydrolysis of phosphodiester linkages between a DNA 3' phosphate and a tyrosine residue as well as a variety of other DNA 3 substituents, the enzyme shows affinity for the substrate increased as the DNA length | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TDP1 | - |
Homo sapiens |
tyrosyl-DNA phosphodiesterase 1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | tyrosyl-DNA phosphodiesterase 1 catalyses the hydrolysis of phosphodiester linkages between a DNA 3' phosphate and a tyrosine residue as well as a variety of other DNA 3 substituents, and is implicated in the repair of covalent complexes involving eukaryotic type IB topoisomerases. Processing by the proteasome is required for TDP1 cleavage in vivo | Homo sapiens |