Literature summary for 3.1.4.1 extracted from

Ortiz-Capisano, M.C.; Liao, T.D.; Ortiz, P.A.; Beierwaltes, W.H.
Calcium-dependent phosphodiesterase 1C inhibits renin release from isolated juxtaglomerular cells (2009), Am. J. Physiol. Regul. Integr. Comp. Physiol., 297, R1469-R1476.

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Inhibitors

Inhibitors	Comment	Organism	Structure
8-methoxymethyl isobutylmethylxanthine	20 microM, 8-MM-IBMX, a selective PDE1 inhibitor, no effect on either JG cell cAMP content or renin release compared to untreated controls	Mus musculus
isobutylmethylxanthine	100 microM, a nonselective PDE1 inhibitor, increases cAMP and renin relase by 72% and 118%, respectively	Mus musculus
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide	W7, 10 microM, a calcium-calmodulin inhibitor	Mus musculus
vinpocetine	40 microM, selective PDE1 inhibitor	Mus musculus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	dependent on, a calcium sensing receptor (CaSR) activation decreases cAMP and renin release and stimulates calcium calmodulin-activated phosphodiesterase	Mus musculus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
80000	-	Western blot analysis of PDE 1A, 1B, and 1C to determine which phosphodiesterase isoform is involved in inhibition of renin release. In conclusion isoform 1C is expressed in isolated JG cells	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	8- to 10-week-old C57/BL6 mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
juxtaglomerular cell	JG cells, isoform 1C, isolated from 8-to 10-week-old C57/BL6 mice, cells in the kidney which synthesize, store and release renin (EC 3.4.23.15)	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
calcium-dependent phosphodiesterase 1C	-	Mus musculus
PDE1	-	Mus musculus
phosphodiesterase 1C	isoform 1C	Mus musculus

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Release 2023.1 (January 2023)