Cloned (Comment) | Organism |
---|---|
both Msx2 and Runx2 are recruited to a conserved core Msx2 binding site within the PC-1 gene promoter upon FGF2 stimulation, promoter analysis, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mutation of the Msx2 DNA binding site, to prevent binding of Msx2 to this site, inhibits PC-1 promoter activity in FGF2 treated MC3T3E1(C4) calvarial pre-osteoblast cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
osteoblast | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
PC-1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | fibroblast growth factor-2, FGF2, specifically induces PC-1 expression in calvarial pre-osteoblasts, which occurs via a transcriptional mechanism involving Runx2. FGF2 promotes Msx2-stimulated PC-1 expression via Frs2/MAPK signaling, Msx2 promotes transcription of the PC-1 gene downstream of FGF2, overview. both Msx2 and Runx2 are recruited to a conserved core Msx2 binding site within the PC-1 gene promoter upon FGF2 stimulation, and that Msx2 and Runx2 function together to induce PC-1 gene expression in osteoblastic cells | up |
General Information | Comment | Organism |
---|---|---|
physiological function | PC-1 is an enzymatic generator of diphosphate and a critical regulator of tissue mineralization | Homo sapiens |