Any feedback?
Literature summary for 3.1.4.1 extracted from
- Biochemical evidence for an ecto alkaline phosphodiesterase I in human airways (2000), Am. J. Respir. Cell Mol. Biol., 23, 255-261.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ADP-ribose | competitive to diuridine tetraphosphate | Homo sapiens |  |
| alpha,beta-methylene-adenosine triphosphate | inhibition in decreasing order: alpha,beta-methyl-adenosine triphosphate, ATP, UTP, GTP, CTP | Homo sapiens | |
| ATP | inhibition in decreasing order: alpha,beta-methylene-adenosine triphosphate, ATP, UTP, GTP, CTP | Homo sapiens | |
| CTP | inhibition in decreasing order: alpha,beta-methylene-adenosine triphosphate, ATP, UTP, GTP, CTP | Homo sapiens | |
| fluoride | - |
Homo sapiens | |
| GTP | inhibition in decreasing order: alpha,beta-methylene-adenosine triphosphate, ATP, UTP, GTP, CTP | Homo sapiens | |
| additional information | not inhibitory: 3-isobutyl-1methylxanthine, Ro 20-1724, 13-dipropyl-8-p-sulfophenylxanthine | Homo sapiens | |
| N-ethylmaleimide | - |
Homo sapiens | |
| nucleoside 5'-triphosphate | - |
Homo sapiens | |
| UTP | inhibition in decreasing order: alpha,beta-methylene-adenosine triphosphate, ATP, UTP, GTP, CTP | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.022 | - |
diuridine tetraphosphate | pH 7.4, 37°C | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epithelial cell | of airway | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP-ribose + H2O | - |
Homo sapiens | ? | - |
? | |
| diadenosine polyphosphate + H2O | - |
Homo sapiens | AMP + adenosine polyphosphate-1 | - |
? | |
| P1,P4-bis(5'-uridyl) tetraphosphate + H2O | - |
Homo sapiens | UMP + uridine 5'-triphosphate | - |
? | |
| thymidine 5'-monophosphate p-nitrophenylester + H2O | - |
Homo sapiens | ? + phosphate | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.023 | - |
ADP-ribose | pH 7.4, 37°C | Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
