Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dexamethasone | increases alkaline phosphodiesterase I in a dose- and time-dependent manner, maximal increase after treatment with 0.001 mM dexamethasone for 5 days, stimulation by dexamethasone is suppressed by cycloheximide and RU 38486 | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
p-Diazobenzenesulfonic acid | DASA: 84% inhibition | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.41 | - |
p-nitrophenylthymidine 5'-phosphate | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasmic membrane | - |
Rattus norvegicus | - |
- |
extracellular | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | phosphodiesterase activity results in the cleavage of nucleotides from nucleic acids and thus may be involved in catabolism of extracellular DNA. Essential function may be to hydrolyze polyribo- and polydeoxyribonucleotides. The enzyme may be important in cell differentiation during carcinogenesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | - |
Rattus norvegicus | - |
mesangial cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA + H2O | - |
Rattus norvegicus | DNA(n-1) + 2'-deoxynucleoside 5'-phosphate | - |
? | |
additional information | phosphodiesterase activity results in the cleavage of nucleotides from nucleic acids and thus may be involved in catabolism of extracellular DNA. Essential function may be to hydrolyze polyribo- and polydeoxyribonucleotides. The enzyme may be important in cell differentiation during carcinogenesis | Rattus norvegicus | ? | - |
? | |
NAD+ + H2O | pyrophosphatase activity | Rattus norvegicus | 5'-AMP + NMN | - |
? | |
oligonucleotides + H2O | - |
Rattus norvegicus | oligonucleotides(n-1) + 5'-mononucleotides | - |
? | |
p-nitrophenylthymidine 5'-phosphate + H2O | - |
Rattus norvegicus | 5'-TMP + p-nitrophenol | - |
? | |
polynucleotides + H2O | specific for 3'-5'-direction from the 3'-hydroxyl terminal in a stepwise manner | Rattus norvegicus | polynucleotides(n-1) + 5'-mononucleotides | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alkaline phosphodiesterase | alkaline phosphodiesterase I | Rattus norvegicus |
nucleotide pyrophosphatase/phosphodiesterase I | membrane alkaline phosphodiesterase is the same enzyme as nucleotide pyrophosphatase | Rattus norvegicus |