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Literature summary for 3.1.4.1 extracted from
- A novel tumor-associated molecular species of 5'-nucleotide phosphodiesterase (1985), Biochem. Biophys. Res. Commun., 130, 1072-1077.
General Stability
| General Stability | Organism |
|---|---|
| dithiothreitol stabilizes, the absence of dithiothreitol during purification results in rapid inactivation | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-crotonyloxymethyl-(4R,5R,6R)-trihydroxy-cyclohex-2-enone | tumor cell line | Mus musculus |  |
| dithiothreitol | liver, spleen, thymus | Mus musculus | |
| N-ethylmaleimide | lymphoblastoma; tumor cell line, N-ethylmaleimide-sensitive | Mus musculus | |
| Naphthomycin | tumor cell line | Mus musculus | |
| Zn2+ | lymphoblastoma; tumor cell line, N-ethylmaleimide-sensitive | Mus musculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.068 | - |
p-nitrophenylthymidine 5'-phosphate | liver of DBA/2 mice | Mus musculus | |
| 1.54 | - |
p-nitrophenylthymidine 5'-phosphate | lymphoblastoma L5178Y | Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasmic membrane | N-ethylmaleimide-sensitive, lymphoblastoma L5178Y | Mus musculus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 140000 | - |
liver, gel filtration | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
DBA/2: liver, spleen, thymus | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial, liver | Mus musculus |
| partial, lymphoblastoma L5178Y | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| L-5178-Y cell | - |
Mus musculus | - |
| liver | dithiothreitol-sensitive | Mus musculus | - |
| spleen | dithiothreitol-sensitive | Mus musculus | - |
| thymus | dithiothreitol-sensitive | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| p-nitrophenylthymidine 5'-phosphate + H2O | - |
Mus musculus | 5'-TMP + p-nitrophenol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 5'-NPDase | - |
Mus musculus |
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Release 2023.1 (January 2023)
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