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Literature summary for 3.1.31.1 extracted from

  • Zhang, Y.; Jia, J.; Li, Y.; Chen, Y.G.; Huang, H.; Qiao, Y.; Zhu, Y.
    Tudor-staphylococcal nuclease regulates the expression and biological function of alkylglycerone phosphate synthase via nuclear factor-kappaB and microRNA-127 in human glioma U87MG cells (2018), Oncol. Lett., 15, 9553-9558 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens Q7KZF4
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Source Tissue

Source Tissue Comment Organism Textmining
U-87MG cell
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Homo sapiens
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Synonyms

Synonyms Comment Organism
Tudor-staphylococcal nuclease
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Homo sapiens

General Information

General Information Comment Organism
physiological function the downregulated expression of Tudor-staphylococcal nuclease can decrease cancer malignancy, and the overexpression can increase viability and migration potential of various tumor cell types. Tudor-SN silencing suppresses the expression of alkylglycerone phosphate synthase (AGPS) and the activity of the mechanistic target of rapamycin (mTOR) signaling pathway. NF-kappaB and miR-127 may be the mediators of Tudor-SN-regulated alkylglycerone phosphate synthase (AGPS) via the mTOR signaling pathway Homo sapiens