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Literature summary for 3.1.31.1 extracted from

  • Olson, M.E.; Nygaard, T.K.; Ackermann, L.; Watkins, R.L.; Zurek, O.W.; Pallister, K.B.; Griffith, S.; Kiedrowski, M.R.; Flack, C.E.; Kavanaugh, J.S.; Kreiswirth, B.N.; Horswill, A.R.; Voyich, J.M.
    Staphylococcus aureus nuclease is an SaeRS-dependent virulence factor (2013), Infect. Immun., 81, 1316-1324.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
SaeRS is required for expression of the nuc gene, expression from plasmid containing the nuc promoter coupled to sGFP (pCM20), transformed into the Staphylococcus aureus USA300 wild-type-LAC and sae, agr, and sigB mutant strains Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
 several strains and isolates
-

Synonyms

Synonyms Comment Organism
staphylococcus aureus nuclease
-
 Staphylococcus aureus

Expression

Organism Comment Expression
Staphylococcus aureus SaeRS is required for expression of the nuc gene additional information

General Information

General Information Comment Organism
physiological function the nuc gene necoding Staphylococcus aureus nuclease is under the control of the SaeRS two-component system, which is a major regulator of Staphylococcus aureus virulence determinants, the enzyme is an SaeRS-dependent virulence factor. With community-associated methicillin-resistant Staphylococcus aureus in a mouse model of peritonitis, in vivo expression of Nuc activity in an SaeRS-dependent manner is observed and determination of Nuc as a virulence factor that is important for in vivo survival, confirming the enzyme's role as a contributor to invasive disease. The enzyme contributes to pathogen survival during invasive disease Staphylococcus aureus