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Literature summary for 3.1.31.1 extracted from

  • Santhekadur, P.K.; Akiel, M.; Emdad, L.; Gredler, R.; Srivastava, J.; Rajasekaran, D.; Robertson, C.L.; Mukhopadhyay, N.D.; Fisher, P.B.; Sarkar, D.
    Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFbeta signaling (2014), FEBS open bio, 4, 353-361.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.31.1

Cloned(Commentary)

Cloned (Comment) Organism
expression in Hep-3B cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information suppression in QGY-7703 cells by si RNA, SND1-17-AT1Rsi Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocellular carcinoma cell Staphylococcal nuclease domain containing-1 is overexpressed in human hepatocellular carcinoma patients Homo sapiens
-
additional information expression of the enzyme and of angiotensin II type 1 receptor are positively correlated Homo sapiens
-
QGY-7703 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
SND1
-
 Homo sapiens
Staphylococcal nuclease domain containing-1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function enzyme hepatocellular carcinoma Staphylococcal nuclease domain containing-1 promotes tumorigenesis in human hepatocellular carcinoma cells. It increases angiotensin II type 1 receptor (AT1R) levels by increasing AT1R mRNA stability. That results in activation of ERK, Smad2 and subsequently the TGFbeta signaling pathway, promoting epithelial-mesenchymal transition and migration and invasion by human hepatocellular carcinoma cells. The enzyme modulates the TGFbeta signaling pathway Homo sapiens