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Literature summary for 3.1.31.1 extracted from

  • Tang, J.; Kang, M.; Chen, H.; Shi, X.; Zhou, R.; Chen, J.; Du, Y.
    The staphylococcal nuclease prevents biofilm formation in Staphylococcus aureus and other biofilm-forming bacteria (2011), Sci. China Life Sci., 54, 863-869.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
gene nuc1, recombinant expression in Escherichia coli strain BL21(DE3) Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
 gene nuc1
-
Staphylococcus aureus RN4220
-
 gene nuc1
-

Synonyms

Synonyms Comment Organism
NUC1
-
 Staphylococcus aureus
staphylococcal nuclease
-
 Staphylococcus aureus

General Information

General Information Comment Organism
malfunction when the nuc1 gene is knocked out, the ability of Staphylococcus aureus strains to form a biofilm significantly increased Staphylococcus aureus
physiological function staphylococcal nuclease is an important virulence factor of Staphylococcus aureus. Biofilm development can be prevented in staphylococcal nuclease-producing strains of Staphylococcus aureus, direct relationship between staphylococcal nuclease production and the prevention of biofilm development, overview. Staphylococcal nuclease affects biofilm formation by other bacteria, such as Pseudomonas aeruginosa and Staphylococcus epidermis. Only bacterial strains that do not possess the nuc1 gene are able to form biofilms Staphylococcus aureus