Application | Comment | Organism |
---|---|---|
medicine | as staphylococcal nuclease domain-containing protein 1 mRNA is overexpressed in cancer cells, the growth of these cells is suppressed following staphylococcal nuclease domain-containing protein 1 knock-down in vitro, thus representing a promising prostate cancer biomarker and therapeutic target, evidence for the diagnostic potential of staphylococcal nuclease domain-containing protein 1 in prostate surgical specimens equivalent or better than that of alpha-methylacyl-CoA racemase | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q7KZF4 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
PC-3 cell | - |
Homo sapiens | - |
prostate cancer cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Epstein-Barr virusencoded transcription factor 2 co-activator p100 | - |
Homo sapiens |
SND1 | - |
Homo sapiens |
staphylococcal nuclease | - |
Homo sapiens |
staphylococcal nuclease domain-containing protein 1 | - |
Homo sapiens |
tudor staphylococcal nuclease | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | in hyperplasia specimens and normal epithelium, protein is weakly or negatively expressed | down |
Homo sapiens | knocked down staphylococcal nuclease domain-containing protein 1 in vitro with small interfering RNA causes a significant decrease in cell growth | additional information |
Homo sapiens | staphylococcal nuclease domain-containing protein 1 is highly expressed in recurrent androgen-insensitive prostate cancer tissues, protein expression intensity increases with increasing grade and aggressiveness of the cancer, staphylococcal nuclease domain-containing protein 1 mRNA is highly expressed in the cytoplasm of cancer cells but is negative to weak in noncancerous cells | up |
General Information | Comment | Organism |
---|---|---|
physiological function | staphylococcal nuclease domain-containing protein 1 is a component of the RNA-induced splicing complex that mediates RNA interference, leading to degradation of specific mRNAs | Homo sapiens |