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Literature summary for 3.1.3.B4 extracted from
- Sac1, a lipid phosphatase at the interface of vesicular and nonvesicular transport (2018), Traffic, 19, 301-318 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endosome | - |
Drosophila melanogaster | 5768 | - |
| endosome | - |
Saccharomyces cerevisiae | 5768 | - |
| Golgi apparatus | - |
Drosophila melanogaster | 5794 | - |
| Golgi apparatus | - |
Saccharomyces cerevisiae | 5794 | - |
| membrane | an integral membrane protein | Drosophila melanogaster | 16020 | - |
| membrane | an integral membrane protein | Saccharomyces cerevisiae | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylinositol 4-phosphate + H2O | Drosophila melanogaster | - |
phosphatidylinositol + phosphate | - |
? |  |
| phosphatidylinositol 4-phosphate + H2O | Saccharomyces cerevisiae | - |
phosphatidylinositol + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| central nervous system | - |
Drosophila melanogaster | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylinositol 4-phosphate + H2O | - |
Drosophila melanogaster | phosphatidylinositol + phosphate | - |
? | |
| phosphatidylinositol 4-phosphate + H2O | - |
Saccharomyces cerevisiae | phosphatidylinositol + phosphate | - |
? | |
| phosphatidylinositol 4-phosphate + H2O | preferred substrate | Saccharomyces cerevisiae | phosphatidylinositol + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 65000, SDS-PAGE | Saccharomyces cerevisiae |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| INPP5f | - |
Drosophila melanogaster |
| INPP5f | - |
Saccharomyces cerevisiae |
| PI 4-phosphatase | - |
Drosophila melanogaster |
| PI 4-phosphatase | - |
Saccharomyces cerevisiae |
| Sac1 | - |
Drosophila melanogaster |
| Sac1 | - |
Saccharomyces cerevisiae |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | in Drosophila development, the enzyme regulates JNK signaling, attenuates Hedgehog signaling, and regulates axon guidance in the embryonic central nervous system. The enzyme is required for postembryonic synaptic maturation and neuronal cell maintenance | Drosophila melanogaster |
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Release 2023.1 (January 2023)
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