Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Mus musculus |
Crystallization (Comment) | Organism |
---|---|
hanging drop vapor diffusion method, using 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.0, and 20% (w/v) PEG3350 | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
C458S | catalytically inactive | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endosome | - |
Mus musculus | 5768 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Co2+ resin column chromatography and gel filtration | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | highest expression | Mus musculus | - |
heart | low expression | Mus musculus | - |
hypothalamus | high expression | Mus musculus | - |
lung | - |
Mus musculus | - |
N2A cell | - |
Mus musculus | - |
pancreas | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme shows no activity on either phosphatidylinositol 4,5-bisphosphate or phosphatidylinositol 3,4,5-triphosphate | Mus musculus | ? | - |
? | |
phosphatidylinositol 4-phosphate + H2O | the enzyme specifically hydrolyzes phosphatidylinositol 4-phosphate in vitro | Mus musculus | phosphatidylinositol + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 128000, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
INPP5f | - |
Mus musculus |
phosphoinositide 4-phosphatase | - |
Mus musculus |
PI 4-phosphatase | - |
Mus musculus |
Sac2 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | genomic ablation of the enzyme causes perturbation on transferrin and integrin recycling as well as defects in cell migration | Mus musculus |