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Literature summary for 3.1.3.B4 extracted from

  • Hsu, F.; Hu, F.; Mao, Y.
    Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recycling (2015), J. Cell Biol., 209, 97-110 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Mus musculus

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method, using 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.0, and 20% (w/v) PEG3350 Mus musculus

Protein Variants

Protein Variants Comment Organism
C458S catalytically inactive Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome
-
Mus musculus 5768
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Co2+ resin column chromatography and gel filtration Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain highest expression Mus musculus
-
heart low expression Mus musculus
-
hypothalamus high expression Mus musculus
-
lung
-
Mus musculus
-
N2A cell
-
Mus musculus
-
pancreas
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme shows no activity on either phosphatidylinositol 4,5-bisphosphate or phosphatidylinositol 3,4,5-triphosphate Mus musculus ?
-
?
phosphatidylinositol 4-phosphate + H2O the enzyme specifically hydrolyzes phosphatidylinositol 4-phosphate in vitro Mus musculus phosphatidylinositol + phosphate
-
?

Subunits

Subunits Comment Organism
? x * 128000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
INPP5f
-
Mus musculus
phosphoinositide 4-phosphatase
-
Mus musculus
PI 4-phosphatase
-
Mus musculus
Sac2
-
Mus musculus

General Information

General Information Comment Organism
malfunction genomic ablation of the enzyme causes perturbation on transferrin and integrin recycling as well as defects in cell migration Mus musculus