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Literature summary for 3.1.3.B4 extracted from

  • Lim, J.M.; Park, S.; Lee, M.S.; Balla, T.; Kang, D.; Rhee, S.G.
    Accumulation of PtdIns(4)P at the Golgi mediated by reversible oxidation of the PtdIns(4)P phosphatase Sac1 by H2O2 (2019), Free Radic. Biol. Med., 130, 426-435 .
    View publication on PubMed
Search for more literature for 3.1.3.B4

Inhibitors

Inhibitors Comment Organism Structure
H2O2 the enzyme undergoes reversible inactivation when its catalytic Cys389 residue is oxidized by exogenous H2O2 to form an intramolecular disulfide with Cys392 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-
Golgi apparatus
-
 Homo sapiens 5794
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidylinositol 4-phosphate + H2O Homo sapiens
-
 phosphatidylinositol + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-431 cell
-
 Homo sapiens
-
AD-293 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylinositol 4-phosphate + H2O
-
 Homo sapiens phosphatidylinositol + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PtdIns(4)P phosphatase
-
 Homo sapiens
Sac1
-
 Homo sapiens