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Literature summary for 3.1.3.B4 extracted from
- Modulation of sphingolipid metabolism by the phosphatidylinositol-4-phosphate phosphatase Sac1p through regulation of phosphatidylinositol in Saccharomyces cerevisiae (2009), J. Biol. Chem., 284, 7588-7596.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Sac1 | - |
Saccharomyces cerevisiae |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | deletion of SAC1 encoding a PtdIns(4)P phosphatase, increases levels of most sphingolipid species, including sphingoid bases, sphingoid base phosphates, and phytoceramide. Deletion of SAC1 dramatically reduces inositol phosphosphingolipids, which result from the addition of a PtdIns-derived phosphoinositol head group to ceramides through Aur1p. Deletion of SAC1 decreases PtdIns dramatically in both steady-state and pulse labeling studies, suggesting that the observed effects on sphingolipids may result from modulation of the availability of PtdIns as a substrate for Aur1p | Saccharomyces cerevisiae |
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