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Literature summary for 3.1.3.9 extracted from

  • Soty, M.; Chilloux, J.; Delalande, F.; Zitoun, C.; Bertile, F.; Mithieux, G.; Gautier-Stein, A.
    Post-translational regulation of the glucose-6-phosphatase complex by cyclic adenosine monophosphate is a crucial determinant of endogenous glucose production and is controlled by the glucose-6-phosphate transporter (2016), J. Proteome Res., 15, 1342-1349 .
    View publication on PubMed
Search for more literature for 3.1.3.9

Activating Compound

Activating Compound Comment Organism Structure
cAMP enzyme activation by cAMP depends on protein kinase A Homo sapiens
forskolin forskolin treatment promotes a 70% stimulation of G6Pase activity. The increase in glucose-6-phosphate transporter activity is required for the stimulation of glucose-6-phosphatase activity by forskolin Homo sapiens

Protein Variants

Protein Variants Comment Organism
T145A the mutation does not affect the enzyme activity compared to the wild type Homo sapiens
T145D the mutation does not affect the enzyme activity compared to the wild type Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucose 6-phosphate + H2O Homo sapiens
-
 D-glucose + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P35575
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
-
 Homo sapiens
-
Hep-G2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate + H2O
-
 Homo sapiens D-glucose + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
G6Pase the enzyme is composed of a glucose-6-phosphate transporter (G6PT) and a catalytic unit (G6PC) Homo sapiens