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Literature summary for 3.1.3.9 extracted from

  • Abbadi, S.; Rodarte, J.J.; Abutaleb, A.; Lavell, E.; Smith, C.L.; Ruff, W.; Schiller, J.; Olivi, A.; Levchenko, A.; Guerrero-Cazares, H.; Quinones-Hinojosa, A.
    Glucose-6-phosphatase is a key metabolic regulator of glioblastoma invasion (2014), Mol. Cancer Res., 12, 1547-1559.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine glucose-6-phosphatase-alpha expression is elevated in glioblastoma when compared to normal brain. Human-derived brain tumor initiating cells utilize the enzyme to counteract glycolytic inhibition induced by 2-deoxy-D-glucose and sustain malignant progression. Down-regulation of the enzyme renders the majority of these cells unable to survive glycolytic inhibition, and promotes glycogen accumulation through the activation of glycogen synthase and inhibition of glycogen phosphorylase. Brain tumor initiating cells that survive enzyme knockdown are less aggressive, displaying reduced migration, invasion, proliferation, and increased astrocytic differentiation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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