Application | Comment | Organism |
---|---|---|
medicine | IGRP is a member of the glucose-6-phosphatase family of proteins and the major autoantigen for autoimmune type 1 diabetes. DR0301-restricted IGRP-specific T cells present in 100% of healthy subjects and type 1 diabetes subjects. DR0401-restricted IGRP-specific T cells present in ca. 80% of the subjects. Cross-reactivity between IGRP and G6Pase-alpha epitopes for DR0401-restricted T cells | Homo sapiens |
medicine | islet-specific glucose-6-phosphatase catalytic subunit-related protein is recognized as a major autoantigen for autoimmune type 1 diabetes. More than 80% of subjects with either DRB1*0401 or DRB1*0301 haplotype have islet-specific glucose-6-phosphatase catalytic subunit-related protein-specific CD4+ T cell responses for at least one islet-specific glucose-6-phosphatase catalytic subunit-related protein epitope. Islet-specific glucose-6-phosphatase catalytic subunit-related protein-specific T cells from both healthy and type 1 diabetes groups produce both gamma-interferon and interleukin-10 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | - |
type 1 diabetes individuals and individuals with a DR0301 or DR0401 haplotype, which are disease susceptible | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | IGRP13-25 and IGRP226-238 are DR0301-restricted epitopes, whereas IGRP23-35 and IGRP247-259 are DR0401-restricted epitopes | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
IGRP | - |
Homo sapiens |
islet-specific glucose-6-phosphatase catalytic subunit-related protein | - |
Homo sapiens |