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Literature summary for 3.1.3.9 extracted from

  • Guigas, B.; Naboulsi, R.; Villanueva, G.R.; Taleux, N.; Lopez-Novoa, J.E.; Leverve, X.M.; El-Mir, M.Y.
    The flavonoid silibinin decreases glucose-6-phosphate hydrolysis in perfused rat hepatocytes by an inhibitory effect on glucose-6-phosphatase (2007), Cell. Physiol. Biochem., 20, 925-934.
    View publication on PubMed
Search for more literature for 3.1.3.9

Application

Application Comment Organism
medicine inhibitory effect of silibinin on both hepatic glucose-6-phosphatase and gluconeogenesis may be of interest in treatment of type 2 diabetes Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
silibinin induces a dose-dependent inhibition of gluconeogenesis associated with a potent decrease in enzyme activity; inhibits gluconeogenesis and D-glucose 6-phosphate hydrolysis from either lactate/pyruvate, glycerol or fructose in a dose-dependent manner. Effect is stronger in intact than in permeabilized microsomes Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.8
-
 D-glucose 6-phosphate control, intact microsomes Rattus norvegicus
5.3
-
 D-glucose 6-phosphate intact microsomes incubated with silibinin Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte microsome Rattus norvegicus
-
hepatocyte perifused hepatocyte Rattus norvegicus
-
liver perifused hepatocyte Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate + H2O
-
 Rattus norvegicus D-glucose + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
G6Pase
-
 Rattus norvegicus
glucose-6-phosphatase
-
 Rattus norvegicus