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Literature summary for 3.1.3.9 extracted from
- Hexokinase and glucose-6-phosphatase activity in woodchuck model of hepatitis virus-induced hepatocellular carcinoma (2006), Comp. Biochem. Physiol. C, 143, 225-231.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics and in vivo assay development | Marmota monax |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Marmota monax | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucose 6-phosphate + H2O | Marmota monax | key enzyme in glucose metabolism | D-glucose + phosphate | - |
ir |  |
| additional information | Marmota monax | reduced enzyme activity in woodchuck model of hepatitis virus-induced hepatocellular carcinoma, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Marmota monax | - |
- |
- |
| Marmota monax | - |
female woodchuck | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hepatoma cell | hepatitis virus-induced hepatocellular carcinoma | Marmota monax | - |
| liver | enzyme activity in healthy and aged liver, activities in different liver regions | Marmota monax | - |
| liver | the woodchuck model of hepatocellular carcinoma has significantly decreased levels of G6Pase compared to healthy woodchuck. Significant differences in G6Pase activity between hepatocellular carcinoma liver region and surrounding normal liver region in the same woodchuck model of hepatocellular carcinoma | Marmota monax | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
activity in woodchuck model of hepatitis virus-induced hepatocellular carcinoma | Marmota monax |
| 0.021 | 0.066 | activity in hepatocellular carcinoma | Marmota monax |
| 0.114 | 0.239 | activity in healthy normal liver | Marmota monax |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-deoxy-2-fluoro-D-glucose 6-phosphate + H2O | 18F-labeled model substrate | Marmota monax | 2-deoxy-2-fluoro-D-glucose + phosphate | - |
ir | |
| 2-deoxy-2-fluoro-D-glucose-6-phosphate + H2O | - |
Marmota monax | 2-deoxy-2-fluoro-D-glucose + phosphate | - |
? | |
| D-glucose 6-phosphate + H2O | - |
Marmota monax | D-glucose + phosphate | - |
ir | |
| D-glucose 6-phosphate + H2O | key enzyme in glucose metabolism | Marmota monax | D-glucose + phosphate | - |
ir | |
| additional information | reduced enzyme activity in woodchuck model of hepatitis virus-induced hepatocellular carcinoma, overview | Marmota monax | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| G6Pase | - |
Marmota monax |
| glucose-6-phosphatase | - |
Marmota monax |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Marmota monax |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
assay at | Marmota monax |
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Release 2023.1 (January 2023)
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