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Literature summary for 3.1.3.9 extracted from

  • Ghosh, A.; Shieh, J.J.; Pan, C.J.; Chou, J.Y.
    Histidine 167 is the phosphate acceptor in glucose-6-phosphatase-b forming a phosphohistidine enzyme intermediate during catalysis (2004), J. Biol. Chem., 279, 12479-12483.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum lumen, the enzyme-alpha and the enzyme-beta are anchored by nine transmembrane helices Homo sapiens 5783
-
membrane
-
Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucose 6-phosphate + H2O Homo sapiens
-
D-glucose + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
the phosphate-enzyme-beta intermediate Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
D-glucose 6-phosphate + H2O = D-glucose + phosphate The enzyme family comprises two active isozyme: the D-glucose 6-phosphatase-alpha, in which is His176 the amino acid in enzyme that acts as the nucleophile forming the phosphohistidine-enzyme intermediate during catalysis and the D-glucose 6-phosphatase-alpha, in which is His167 the amino acid in enzyme that acts as the nucleophile forming the phosphohistidine-enzyme intermediate during catalysis. Both enzyme-alpha and enzyme-beta couple with the D-glucose 6-phosphate transporter to form an active enzyme complex Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
Homo sapiens
-
kidney
-
Homo sapiens
-
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate + H2O
-
Homo sapiens D-glucose + phosphate
-
?