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Literature summary for 3.1.3.86 extracted from

  • Rajadurai, C.V.; Havrylov, S.; Coelho, P.P.; Ratcliffe, C.D.; Zaoui, K.; Huang, B.H.; Monast, A.; Chughtai, N.; Sangwan, V.; Gertler, F.B.; Siegel, P.M.; Park, M.
    5-Inositol phosphatase SHIP2 recruits Mena to stabilize invadopodia for cancer cell invasion (2016), J. Cell Biol., 214, 719-734 .
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
D608A catalytically inactive Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O Homo sapiens
-
 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O15357
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MDA-MB-231 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O
-
 Homo sapiens 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 150000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
5'-inositol phosphatase
-
 Homo sapiens
SHIP2
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction disruption of the enzyme-Mena interaction in cancer cells leads to attenuated capacity for extracellular matrix degradation and invasion in vitro, as well as reduced metastasis in vivo Homo sapiens
physiological function the enzyme SHIP2 recruits Mena, but not vasodilator-stimulated phosphoprotein, to invadopodia Homo sapiens