Activating Compound | Comment | Organism | Structure |
---|---|---|---|
AQX-016A | - |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R)-2-[(S)-hydroxy(2-phenylbenzo[h]quinolin-4-yl)methyl]piperidin-1-ium | - |
Homo sapiens | |
(2R)-2-[(S)-[5,7-dichloro-3-adamantyl)naphthalen-1-yl](hydroxy)methyl]piperidin-1-ium | - |
Homo sapiens | |
2-[1-[(2,4-dichlorophenyl)methyl]-2-methyl-5-(methylsulfanyl)-1H-indol-3-yl]ethan-1-aminium | 40% inhibition at 0.5 mM | Homo sapiens | |
2-[1-[(2-chlorophenyl)methyl]-2-methyl-5-(methylsulfanyl)-1H-indol-3-yl]ethan-1-aminium | - |
Homo sapiens | |
3-[(2,4-dichlorophenyl)methoxy]-N-[(2,6-difluorophenyl)methyl]thiophene-2-carboxamide | AS1938909, competitive inhibitor of SHIP2 | Homo sapiens | |
3-[(4-chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide | AS1949490, competitive inhibitor of SHIP2 | Homo sapiens | |
benzene 1,2,3,4-tetrayl tetrakis(phosphate) | - |
Homo sapiens | |
benzene 1,2,3,5-tetrayl tetrakis(phosphate) | - |
Homo sapiens | |
benzene 1,2,4,5-tetrayl tetrakis(phosphate) | - |
Homo sapiens | |
biphenyl 2,3',4,5',6-pentayl pentakis(phosphate) | - |
Homo sapiens | |
additional information | not inhibited by 3-alpha-aminocholestane | Homo sapiens | |
N-(4-[[(4-chlorophenyl)methoxy]methyl]pyridin-2-yl)-2-phenylacetamide | - |
Homo sapiens | |
N-(4-[[(4-chlorophenyl)methoxy]methyl]pyridin-2-yl)-3-phenylpropanamide | - |
Homo sapiens | |
N-[4-[(4-chlorophenyl)methoxy]pyridin-2-yl]-2-(2,6-difluorophenyl)acetamide | - |
Homo sapiens | |
N-[4-[(4-chlorophenyl)methoxy]pyridin-2-yl]-2-phenylacetamide | - |
Homo sapiens | |
N-[4-[(4-chlorophenyl)methoxy]pyridin-2-yl]-3-phenylpropanamide | - |
Homo sapiens | |
NGD-61338 | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O | Homo sapiens | - |
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15357 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
3T3-L1 cell | - |
Homo sapiens | - |
breast cancer cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
K-562 cell | - |
Homo sapiens | - |
laryngeal squamous cell carcinoma cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
U-251 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O | - |
Homo sapiens | 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
INPPL1 | - |
Homo sapiens |
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 | - |
Homo sapiens |
SHIP2 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00057 | - |
3-[(2,4-dichlorophenyl)methoxy]-N-[(2,6-difluorophenyl)methyl]thiophene-2-carboxamide | pH and temperature not specified in the publication | Homo sapiens | |
0.00062 | - |
3-[(4-chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide | pH and temperature not specified in the publication | Homo sapiens | |
0.03 | - |
(2R)-2-[(S)-hydroxy(2-phenylbenzo[h]quinolin-4-yl)methyl]piperidin-1-ium | pH and temperature not specified in the publication | Homo sapiens | |
0.063 | - |
(2R)-2-[(S)-[5,7-dichloro-3-adamantyl)naphthalen-1-yl](hydroxy)methyl]piperidin-1-ium | pH and temperature not specified in the publication | Homo sapiens | |
0.5 | - |
2-[1-[(2-chlorophenyl)methyl]-2-methyl-5-(methylsulfanyl)-1H-indol-3-yl]ethan-1-aminium | pH and temperature not specified in the publication | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00057 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[(2,4-dichlorophenyl)methoxy]-N-[(2,6-difluorophenyl)methyl]thiophene-2-carboxamide | |
0.00062 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[(4-chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide | |
0.03 | - |
pH and temperature not specified in the publication | Homo sapiens | (2R)-2-[(S)-hydroxy(2-phenylbenzo[h]quinolin-4-yl)methyl]piperidin-1-ium | |
0.063 | - |
pH and temperature not specified in the publication | Homo sapiens | (2R)-2-[(S)-[5,7-dichloro-3-adamantyl)naphthalen-1-yl](hydroxy)methyl]piperidin-1-ium | |
0.5 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[1-[(2-chlorophenyl)methyl]-2-methyl-5-(methylsulfanyl)-1H-indol-3-yl]ethan-1-aminium |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | virusecurinine, a plant alkaloid, downregulates enzyme expression | down |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme mutations are associated with opsismodysplasia. Mice expressing a germline catalytically inactive SHIP2 mutant protein are viable, but have defects in the development of muscle, adipose tissue and the female genital tract, as well as in somatic growth | Homo sapiens |
physiological function | the enzyme is involved in insulin signalling | Homo sapiens |