Cloned (Comment) | Organism |
---|---|
expressed in COS-7 cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Homo sapiens | 5886 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
160000 | - |
full-length enzyme, gel filtration | Homo sapiens |
170000 | - |
phosphorylated protein, gel filtration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | in COS-7 cells, SHIP2 is tyrosine-phosphorylated at least at two separated tyrosine phosphorylation sites in response to epidermal growth factor | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O | - |
Homo sapiens | 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SH2 domain containing inositol 5-phosphatase 2 | - |
Homo sapiens |
SHIP2 | - |
Homo sapiens |
Src homology 2 domain containing inositol 5-phosphatase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the enzyme is stimulated by 50 ng/ml epidermal growth factor | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in epidermal growth factor-stimulated COS-7 cells | Homo sapiens |