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Literature summary for 3.1.3.86 extracted from

  • Pesesse, X.; Dewaste, V.; De Smedt, F.; Laffargue, M.; Giuriato, S.; Moreau, C.; Payrastre, B.; Erneux, C.
    The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells (2001), J. Biol. Chem., 276, 28348-28355.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-7 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
Homo sapiens 5886
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
160000
-
full-length enzyme, gel filtration Homo sapiens
170000
-
phosphorylated protein, gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein in COS-7 cells, SHIP2 is tyrosine-phosphorylated at least at two separated tyrosine phosphorylation sites in response to epidermal growth factor Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O
-
Homo sapiens 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
?

Synonyms

Synonyms Comment Organism
SH2 domain containing inositol 5-phosphatase 2
-
Homo sapiens
SHIP2
-
Homo sapiens
Src homology 2 domain containing inositol 5-phosphatase
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is stimulated by 50 ng/ml epidermal growth factor up

General Information

General Information Comment Organism
physiological function the Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in epidermal growth factor-stimulated COS-7 cells Homo sapiens