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Literature summary for 3.1.3.86 extracted from

  • Pesesse, X.; Moreau, C.; Drayer, A.L.; Woscholski, R.; Parker, P.; Erneux, C.
    The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity (1998), FEBS Lett., 437, 301-303.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli DH5alphaF' cells and in COS-7 cells Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
103000
-
 catalytic part of SHIP2, gel filtration Homo sapiens
145000
-
 full-length enzyme, gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni2+-agarose column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
hematopoietic cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Homo sapiens 1-phosphatidyl-1D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O
-
 Homo sapiens 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PtdIns(3,4,5)P3 phosphatase
-
 Homo sapiens
SH2 domain containing inositol 5-phosphatase
-
 Homo sapiens
SHIP2
-
 Homo sapiens